Authors: Ashelyn E Sidders, Lauren C Radlinski, Sarah E Rowe, & Brian P Conlon
Journal: Methods in molecular biology
PMID: 34590262
Abstract: Aminoglycosides are bactericidal drugs which require a proton motive force (PMF) for uptake into the bacterial cell. Low energy cells, such as persisters, maintain a PMF below the threshold for drug uptake and are tolerant to aminoglycosides. In this chapter, we discuss mechanisms to target the bacterial membrane and stimulate aminoglycoside uptake to kill Staphylococcus aureus persisters.