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Improving Antibiotic Efficacy Research in the News
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Diabetes potentiates the emergence and expansion of antibiotic resistance
Diabetes potentiates the emergence and expansion of antibiotic resistance
Brian ConlonFebruary 25, 2025Conlon Lab
Palmitoleic acid sensitizes vancomycin-resistant Staphylococcus aureus to vancomycin by outpacing the expression of resistance genes
Palmitoleic acid sensitizes vancomycin-resistant Staphylococcus aureus to vancomycin by outpacing the expression of resistance genes
Brian ConlonFebruary 25, 2025Conlon Lab
Ultrasound-Mediated Antibiotic Delivery to In Vivo Biofilm Infections: A Review
Ultrasound-Mediated Antibiotic Delivery to In Vivo Biofilm Infections: A Review
Brian ConlonFebruary 25, 2025Conlon Lab
Host stress drives tolerance and persistence: The bane of anti-microbial therapeutics
Host stress drives tolerance and persistence: The bane of anti-microbial therapeutics
Brian ConlonFebruary 25, 2025Conlon Lab
In-patient evolution of a high-persister Escherichia coli strain with reduced in vivo antibiotic susceptibility
In-patient evolution of a high-persister Escherichia coli strain with reduced in vivo antibiotic susceptibility
Brian ConlonFebruary 25, 2025Conlon Lab
Inflammasome-mediated glucose limitation induces antibiotic tolerance in Staphylococcus aureus
Inflammasome-mediated glucose limitation induces antibiotic tolerance in Staphylococcus aureus
Brian ConlonFebruary 25, 2025Conlon Lab
Hydrogen Peroxide, Povidone-Iodine and Chlorhexidine Fail to Eradicate Staphylococcus aureus Biofilm from Infected Implant Materials
Hydrogen Peroxide, Povidone-Iodine and Chlorhexidine Fail to Eradicate Staphylococcus aureus Biofilm from Infected Implant Materials

Authors: Dana M. Parker, John A. Koch, Charles G. Gish, Kimberly M. Brothers, William Li, Jessica Gilbertie, Sarah E. Rowe, Brian P. Conlon, Venkata K. C. Byrapogu, and Kenneth L. Urish
Journal: Life (Basel)
PMID: 37374013

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Brian ConlonJune 13, 2023Conlon Lab
Overcoming biological barriers to improve treatment of a Staphylococcus aureus wound infection
Overcoming biological barriers to improve treatment of a Staphylococcus aureus wound infection

Authors: Virginie Papadopoulou, Ashelyn E Sidders, Kuan-Yi Lu, Amanda Z Velez, Phillip G Durham, Duyen T Bui, Michelle Angeles-Solano, Paul A Dayton, & Sarah E Rowe 
Journal: Cell chemical biology
PMID: 37148883

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Brian ConlonMay 18, 2023Conlon Lab
Antibiotic-induced accumulation of lipid II synergizes with antimicrobial fatty acids to eradicate bacterial populations
Antibiotic-induced accumulation of lipid II synergizes with antimicrobial fatty acids to eradicate bacterial populations

Authors: Ashelyn E Sidders, Katarzyna M Kedziora, Melina Arts, Jan-Martin Daniel, Stefania de Benedetti, Jenna E Beam, Duyen T Bui, Joshua B Parsons, Tanja Schneider, Sarah E Rowe, & Brian P Conlon
Journal: eLife
PMID: 36876902

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Brian ConlonMarch 21, 2023Conlon Lab
Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia: Host, Pathogen, and Treatment
Persistent Methicillin-Resistant Staphylococcus aureus Bacteremia: Host, Pathogen, and Treatment

Authors: Joshua B Parsons, Annette C Westgeest, Brian P Conlon, & Vance G Fowler Jr
Journal: Antibiotics

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Brian ConlonFebruary 24, 2023Conlon Lab
Antibiotic Tolerance and Treatment Outcomes in Cystic Fibrosis Methicillin-Resistant Staphylococcus aureus Infections
Antibiotic Tolerance and Treatment Outcomes in Cystic Fibrosis Methicillin-Resistant Staphylococcus aureus Infections

Authors: Kuan-Yi Lu, Nikki J Wagner, Amanda Z Velez, Agathe Ceppe, Brian P Conlon, & Marianne S Muhlebach
Journal: Microbiology spectrum
PMID: 36519944

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Brian ConlonFebruary 14, 2023Conlon Lab
The Use of Acute Immunosuppressive Therapy to Improve Antibiotic Efficacy against Intracellular Staphylococcus aureus
The Use of Acute Immunosuppressive Therapy to Improve Antibiotic Efficacy against Intracellular Staphylococcus aureus

Authors: Jenna E Beam, Sophie Maiocchi, Ana Cartaya, Sarah E Rowe, Edward S M Bahnson, & Brian P Conlon
Journal: Microbiology spectrum
PMID: 35575507

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Brian ConlonMay 17, 20222022, Conlon Lab
Fibrin(ogen) engagement of S. aureus promotes the host antimicrobial response and suppression of microbe dissemination following peritoneal infection
Fibrin(ogen) engagement of S. aureus promotes the host antimicrobial response and suppression of microbe dissemination following peritoneal infection

Authors: Oscar Negrón, Woosuk S. Hur, Joni Prasad, David S. Paul, Sarah E. Rowe, Jay L. Degen, Sara R. Abrahams, Silvio Antoniak, Brian P. Conlon, Wolfgang Bergmeier, Magnus Hӧӧk, Matthew J. Flick

Journal: PLOS Pathogens

PMID: 35041705

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Brian ConlonJanuary 18, 2022Conlon Lab
Stimulating Aminoglycoside Uptake to Kill Staphylococcus aureus Persisters
Stimulating Aminoglycoside Uptake to Kill Staphylococcus aureus Persisters

Authors: Ashelyn E Sidders, Lauren C Radlinski, Sarah E Rowe, and Brian P Conlon
Journal: Methods in molecular biology
PMID: 34590262

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Brian ConlonOctober 19, 20212021, Conlon Lab
Shooting yourself in the foot: How immune cells induce antibiotic tolerance in microbial pathogens
Shooting yourself in the foot: How immune cells induce antibiotic tolerance in microbial pathogens

Authors: Jenna E. Beam, Sarah E. Rowe, & Brian P. Conlon
Journal: PLoS Pathogens
PMID: 34293056

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Brian ConlonJuly 22, 20212021, Conlon Lab
Macrophage-produced peroxynitrite induces antibiotic tolerance and supersedes intrinsic mechanisms of persister formation
Macrophage-produced peroxynitrite induces antibiotic tolerance and supersedes intrinsic mechanisms of persister formation

Authors: Jenna E. Beam, Nikki J. Wagner, John C. Shook, Edward S. M. Bahnson, Vance G. Fowler Jr., Sarah E. Rowe, & Brian P. Conlon
Journal: Infection and Immunity
PMID: 34097475

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Brian ConlonJune 7, 20212021, Conlon Lab
Harnessing ultrasound-stimulated phase change contrast agents to improve antibiotic efficacy against methicillin-resistant Staphylococcus aureus biofilms
Harnessing ultrasound-stimulated phase change contrast agents to improve antibiotic efficacy against methicillin-resistant Staphylococcus aureus biofilms

Authors: Philip G. Durham, Ashelyn E. Sidders, Jenna E. Beam, Katarzyna M. Kedziora, Paul A. Dayton, Brian P. Conlon, Virginie Papadopoulou, & Sarah E. Rowe
Journal: Biofilm
PMID: 34124645

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Brian ConlonMay 11, 20212021, Conlon Lab
Recalcitrant Staphylococcus aureus Infections: Obstacles and Solutions
Recalcitrant Staphylococcus aureus Infections: Obstacles and Solutions

Authors: Sarah E. Rowe, Jenna E. Beam, & Brian P. Conlon
Journal: Infection and Immunity
PMID: 33526569

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Brian ConlonMarch 17, 2021Conlon Lab, 2021
Reactive oxygen species induce antibiotic tolerance during systemic Staphylococcus aureus infection
Reactive oxygen species induce antibiotic tolerance during systemic Staphylococcus aureus infection

Authors: Sarah E. Rowe, Nikki J. Wagner, Lupeng Li, Jenna E. Beam, Alec D. Wilkinson, Lauren C. Radlinski, Qing Zhang, Edward A. Miao & Brian P. Conlon
Journal: Nature Microbiology
PMID: 31819212

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Nature MicrobiologyBrian ConlonJanuary 1, 20202019, Conlon Lab
Chemical Induction of Aminoglycoside Uptake Overcomes Antibiotic Tolerance and Resistance in Staphylococcus aureus
Chemical Induction of Aminoglycoside Uptake Overcomes Antibiotic Tolerance and Resistance in Staphylococcus aureus

Authors: Lauren C. Radlinski, Sarah E. Rowe, Robert Brzozowski, Alec D. Wilkinson, Rennica Huang, Prahathees Eswara, and Brian P. Conlon
Journal: Cell Chemical Biology
PMID: 31402316

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Conlon LabOctober 17, 2019Conlon Lab
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